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RELIEF that there’s a treatment for my GPP

SPEVIGO is the only FDA-approved treatment specifically for generalized pustular psoriasis (GPP)

SPEVIGO addresses a primary cause of GPP

Keyhole with fire symbolizing IL-36 pathway imbalance in GPP

The barrier:
an imbalance in the IL-36 pathway

GPP, or generalized pustular psoriasis, is caused by an imbalance in a part of your immune system known as the interleukin-36 (or IL-36) pathway. When this pathway is out of balance, your body experiences ongoing and potentially life-threatening inflammation.

Gold key with GPP letters symbolizing how treatment works

The key:
how SPEVIGO works

SPEVIGO is the only FDA-approved therapy for GPP. It helps control the activity of the IL-36 pathway, addressing GPP inflammation within the body, including the skin.

SPEVIGO is a type of treatment known as a biologic. It works within the body to target and address a specific part of the IL-36 pathway that causes inflammation in GPP. The precise way IL-36 activity may impact the treatment of GPP flares is not fully understood.

Two forms of SPEVIGO to cover 2 different treatment needs

Icon of a syringe representing SPEVIGO SC monthly treatment for GPP

SPEVIGO SC

A monthly treatment that may be taken at home to help reduce the risk of a GPP flare (your doctor will show you how)

IV bag icon representing Spevigo IV infusion treatment

SPEVIGO IV

A different form given at an infusion center or hospital to treat an active GPP flare

For some people, SPEVIGO IV may be used to treat an initial active flare, and then SPEVIGO SC is used as an ongoing treatment to help reduce the risk of future flares. Your doctor will determine which is appropriate for you. 

“Having a treatment specific to GPP... it’s a new beginning for me.”

Jordan, whose choice is SPEVIGO. She has been compensated for the time spent to share her story.

Jordan smiling and standing by a ballet barre, living her life with GPP after treatment with Spevigo

Support tailored to your needs

The SPEVIGO Patient Support Program is a complimentary support program here to help you on your journey. Get connected to a dedicated team member who can answer your questions, explore financial support, and help you prepare for treatment.

Call 1-833-SPEVIGO to get started

Monday-Friday, 8AM-8PM ET

Once you enroll, we can:

Umbrella icon for insurance coverage support

Help

explore insurance coverage, including understanding anticipated out-of-pocket costs

Folder icon representing SPEGIVO financial assistance and copay program

Explain

potential financial assistance options, including the SPEVIGO Copay Program*

Person icon symbolizing patient connection with SPEGIVO clinical educator

Connect

you to resources about GPP, including how it may affect your body, how SPEVIGO works, what to expect on treatment, how SPEVIGO is administered, and how to inject it

*Eligibility and enrollment required. For use only with commercial prescription insurance. Valid for US patients, aged 12 years and older. Must be used for an FDA-approved indication. Additional terms and conditions apply.

IV=intravenous.
SC=subcutaneous.

What is SPEVIGO?

SPEVIGO is a prescription medicine used to treat generalized pustular psoriasis (GPP) in adults and children 12 years of age and older who weigh at least 88 pounds (40 kg). It is not known if SPEVIGO is safe and effective in children under 12 years of age or who weigh less than 88 pounds (40 kg). 

Please see the Medication Guide and Instructions for Use.

Important Safety Information

Do not receive SPEVIGO if you or your child have had a severe or life-threatening allergic reaction to spesolimab-sbzo or any of the ingredients in SPEVIGO.  

What is the most important information I should know about SPEVIGO?

SPEVIGO may cause serious side effects, including:

  • Infections. SPEVIGO may lower the ability of your or your child’s immune system to fight infections and may increase your or your child’s risk of infections. Your healthcare provider should check you or your child for infections and tuberculosis (TB) before starting treatment with SPEVIGO and may treat you or your child for TB before you begin treatment with SPEVIGO if you have a history of TB or have active TB. Your healthcare provider should watch you or your child closely for signs and symptoms of TB during or after treatment with SPEVIGO. Tell your healthcare provider right away if you or your child have an infection or have symptoms of an infection during or after treatment with SPEVIGO, including:
    • fevers, chills, or sweats
    • muscle aches
    • cough
    • shortness of breath
    • blood in your phlegm (mucus)
    • burning when you urinate
    • urinating more often than normal
  • Allergic reactions and infusion-related reactions. Serious allergic reactions may happen during or after your or your child’s SPEVIGO injection. If you or your child have a serious allergic reaction, your healthcare provider will stop treatment with SPEVIGO. If you or your child are given SPEVIGO in a vein (intravenously) and have an infusion-related reaction, your healthcare provider will stop your or your child’s SPEVIGO infusion and treat your or your child’s symptoms and may restart SPEVIGO at a slower infusion rate. Tell your healthcare provider or get emergency medical help right away if you or your child get any of the following symptoms during or after your or your child’s SPEVIGO injection: 
    • feeling faint, dizzy, or lightheaded
    • swelling of your face, eyelids, lips, mouth, tongue, or throat
    • trouble breathing or throat tightness
    • fever
    • mouth sores
    • chest tightness
    • hives or skin rash that is different than the rash from generalized pustular psoriasis (GPP)
    • itching
    • swollen lymph nodes

Before you or your child receive SPEVIGO, tell your healthcare provider about all of your medical conditions, including if you or your child:

  • have an infection that does not go away or that keeps coming back.
  • have TB or have been in close contact with someone with TB.
  • have recently received or are scheduled to receive an immunization (vaccine). You or your child should not receive live vaccines during and for at least 16 weeks after treatment with SPEVIGO. You or your child should be brought up to date with all vaccines before starting SPEVIGO.
  • are pregnant or plan to become pregnant. It is not known if SPEVIGO can harm your or your child’s unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if SPEVIGO passes into your breast milk. Talk to your healthcare provider about the best way to feed your or your child’s baby during treatment with SPEVIGO.

Tell your healthcare provider about all the medicines you or your child take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of SPEVIGO?

The most common side effects of SPEVIGO given in a vein (intravenously) for GPP flare treatment include:

  • feeling tired or weak
  • headache
  • nausea
  • itching or itchy bumps
  • a collection of blood under the skin at the infusion site or bruising
  • urinary tract infection

The most common side effects of SPEVIGO when given under the skin (subcutaneously) for treatment of GPP when not experiencing a flare include:

  • redness, pain, swelling, hardening, hives, or warmth at the injection site
  • joint pain
  • urinary tract infection
  • itching

These are not all of the possible side effects of SPEVIGO. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see the Medication Guide and Instructions for Use.

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